Patent
1. Le, H. V.; Paris, J. R.; Mahdi, F.; Khan, M. I. H.; International/U.S. Patent Application PCT/US2022/075220 (filed August 19, 2022). Allopregnanolone Analogues for HIV Viremia and Neurotoxicity Protection.
2. Le, H.V.; Kim, S.J.; Khan, M.I.H; UM 9320 - US Provisional (2022) Cytochrome bc1 Complex Inhibitors and Methods of Use Thereof
Postdoctoral publications
1. Novak, E.; Khan, M.I.H. Murcek A.M.; Gryder, B.E.* Targeted Reprogramming of Androgen Receptor Function by Chemically Induced Proximity (in preparation)
2. Chin, D.H.; Pontius, W.D.; Lizardo, M.M.; Chakraborty, M.; Gomez, R.; Sharma, A.; Khanna, A.; Sharma, N.; Asante, Y.; Kim, H.; Aloisi, S.; Udhayakumar, B.; Rotariu, E.L; Chang, M.S.; Bartels, C.F.; Khan, M.I.H.; Cawley, J.R.; Liemisa, B.; Garcia, L.J.; Budhathoki, Y.; Gross, A.C.; Cannon, M.V.; Ryan, L.; McEachron, T.A.; Wolf, I.; Dries, R.; Gray, N.S.; Scacheri, P.C.; sallari, R.; George, R.; Roberts, R.D.; Gryder, B.E.* RUNX2 is essential for active chromatin clusters in osteosarcoma and is vulnerable to p300 inhibition. 2026 (to be submitted)
3. Khan, M.I.H.,†,* Chang M.S.,† Asante Y., Al-Haddad M.K., Kukhta T., Udhayakumar B., Garzón-Porras A.M., Rotariu E., Aneja S., Kelly J.L., Farma-Hai C.B., Ullal K., Chin D.H., Federation A.J., Pino L.K., Robbins J., Wachtel M., Stauffer S.R., Gryder B.E.* CpG density predicts CBP/p300 dependency across 3D chromatin clusters. doi.org/10.64898/2026.05.04.722036 2026 (*co-corresponding author, under review)
4. Asante, Y.; Benischke, K.; Osman, I.; Ngo, Q.A.; Wurth, J.; Laubscher, D.; Kim, H.; Udhayakumar, B.; Khan, M.I.H.; Chin, D.H.; Porch, J.; Chakraborty, M.; Sallari, R.; Delattre, O.; Zaidi, S.; Morice, S.; Surdez, D.; Danielli, S.G.; Schäfer, B.W.; Gryder, B.E.;* Wachtel, M.;* PAX3-FOXO1 uses its activation domain to recruit CBP/P300 and shape RNA Pol2 cluster distribution. Nature Communications 2023, 14 (1), 8361. doi.org/10.10 38/s41467-023-43780-4
Predoctoral publications (10)
5. Khan, M.I.H.; Yang, J.; Kim, S.J.; Le, H.V.; A mild and catalyst-free α-benzoyloxylation of tertiary amides. Medicinal Chemistry Research, 2025, 34, 849–854 (2025). https://doi.org/10.1007/s00044-025-03381-w</p>
6. Kim, S.J.; Khan, M.I.H.; Alden, S.; Charles, L.; Le, H.V.; Chemical structure-biological activity of 1,4-naphthoquinone analogs as potential Aedes aegypti larvicides. Pest Management Science. 2025, 81, 6, 2881-2890. doi.org/10.1002/ps.8656
7. Akins, N.S.; Mohammed, S.F.; Pandey, P.; Kim, S.J.; Mahdi, F.; Khan, M.I.H.; Moss, E.; Worth, C.; Keanne, M.M.; Chittiboyina, A.G.; Doerksen, R.J.; Paris, J.J.; Le, H.V.;* Alleviation of Cocaine Withdrawal and Pertinent Interactions between Salvinorin-based Antagonists and Kappa Opioid Receptor. ACS Chemical Neuroscience; 2023, 14, 5, 958–976
8. Kdimy, A.; Kim, S.J.; Ali, Z.; Khan, M.I.H.; Tripathi, S. K.; Hajjaji, S.E.;* Le, H.V.;* Two Phthalate and Terephthalate Plasticizers Unprecedently Isolated from Capparis spinosa L. Leaves. Chemistry and Biodiversity; 2023,20, e2023009
9. Khan, M.I.H.; Mahdi, F.; Penfornis, P.; Akins, N.S.; Hossain, M.I.; Kim, S.J.; Sulochana, S.P.; Adam, A.T.; Tran, T.D.; Tan, C.; Claudio, P.P.; Paris, J.J.; Le, H.V.;* Synthesis and Biological Evaluation of tert-Butyl Ester and Ethyl Ester Prodrugs L-γ-Methyleneglutamic Acid Amides for Cancer. Bioorganic and Medicinal Chemistry 2022, 78, 117137
10. Khan, M.I.H.; Akins, N.S.; Sawyer, B.J.; Le, H.V.;* A Comprehensive and Systematic Review on the Kappa Opioid Receptor and Its Ligands: New Directions for the Treatment of Pain, Anxiety, Depression, and Drug Abuse. European Journal of Medicinal Chemistry; 2022, 243, 114785.
11. Hossain, M.I.; Khan, M.I.H.; Kim, S.J.; Le, H.V.;* Synthesis of 3,4,5-Trisubstituted Isoxazoles in Water via a [3+2]-Cycloaddition of Nitrile Oxides and 1,3-Diketones, β-Ketoesters, or β-Ketoamides: Base-mediated and Keto-enol-controlled Mechanism. Beilstein Journal of Organic Chemistry; 2022, 18, 446-458.
12. Sawyer, B.J.; Khan, M.I.H.; Le, H.V.; Medicinal Chemistry of Chemotherapeutic Agents; Chapter: Antimalarial drugs; Elsevier Academic Press 2022; ISBN: 9780323905756
13. Ahamed, S.K.; Khan, M.I.H.; Billah, M.M.; Hossain, M.S.;* Methanol Extract of Solanum Violaceum Root Possesses Antiobesity, Hypolipidemic, Thrombolytic, and Membrane Stabilizing Activity; Journal of Research in Pharmacy, 2017, 22,1. DOI : 10.12991/mpj.2018.47
14. Khan, M.I.H.; Sohrab, H.; Rony, S.R.; Tareq, F.S.; Hasan, C.M.; Mazid, M.A.;* Cytotoxic and antibacterial naphthoquinones from an endophytic fungus, Cladosporium sp.; Toxicology Reports; 2016, 3, 861-865.
To be submitted (08)
15. Khan, M.I.H.; Budhathoki, S.; Kim, S.J.; Alam, M.; Khan, S.I.; Le, H.V.* Design, synthesis, and structure-activity relationships of (Phenoxyphenyl)-1,4-Naphthoquinone-based compounds against methicillin-resistant S. aureus.
16. Khan, M.I.H.; Kim, S.J.; Roth, B; Le, H.V.* Development of a novel Salvinorin-Based Selective Kappa Opioid Receptor Agonist.
17. Khan, M.I.H.; Hossain, M.I.; Butch, E.R.; Snyder, S.E.; Le, H.V.; Synthesis and biological evaluation of novel PET imaging agent.
18. Akins, N.S; Khan, M.I.H.; Kim, S.J.; Le, H.V.* Discovery of Salvinorin Amide Derivatives as MOR-Preferring Dual KOR/MOR Agonists.
19. Khan, M.I.H; Akins, N.S.; Kim, S.J.; Le, H.V.* Tetrazole derivatives of Salvinorin as dual agonist of KOR and MOR.
20. Kim, S.J.; Li, Y.; Mahoney, A.R.; Khan, M.I.H.; Tripathi, S.K.; Khan, S.I.; Wuest, W.M.; Riscoe, M; Le, H.V.;* Novel 2-Hydroxy-1,4-naphthoquinones as Drug-resistant Antimalarials and Antibacterials.
21. Khan, M.I.H.; Mahdi, F.; Elhanafy, E.; Salahuddin, M.F.; Akins, N.S.; Kim, S.J.; Li, J.;* Paris, J.J.;* Le, H.V.* Discovery of allopregnanolone-based analogue as a neuroprotective agent against HIV.
22. Mahdi, F.; Elhanafy, E.; Khan, M.I.H.; Akins, N.S.; Kim, S.J.; Li, J.;* Paris, J.J.;* Le, H.V.* Discovery of allopregnanolone-based analogue as an anti-viremic agent against HIV.